Drug interactions
Mifepristone + Paclitaxel
Severity: Moderate
Mifepristone and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is cleared partly by CYP3A4 and CYP2C8. Mifepristone inhibits CYP3A4 and may raise paclitaxel exposure, increasing the risk of myelosuppression and peripheral neuropathy.
What this interaction means in plain words
Mifepristone and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Paclitaxel belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4-mediated metabolism of paclitaxel.
What to do
Prefer an alternative to mifepristone where possible. If used together, monitor blood counts and neuropathy and reduce the paclitaxel dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Mifepristone with Paclitaxel?
MediHelp rates the interaction as moderate. Mifepristone and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is cleared partly by CYP3A4 and CYP2C8. Mifepristone inhibits CYP3A4 and may raise paclitaxel exposure, increasing the risk of myelosuppression and peripheral neuropathy.
How serious is the interaction between Mifepristone and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to mifepristone where possible. If used together, monitor blood counts and neuropathy and reduce the paclitaxel dose as needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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