Drug interactions
Mifepristone + Paricalcitol
Severity: Minor
Mifepristone and Paricalcitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise paricalcitol exposure by inhibiting CYP3A4, one of the enzymes that metabolize it. The clinical effect is probably small, but excess vitamin D activity could cause hypercalcemia.
What this interaction means in plain words
Mifepristone and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Paricalcitol belongs to Musculoskeletal.
Why it happens
Mifepristone inhibits CYP3A4, modestly reducing paricalcitol clearance.
What to do
Monitor serum calcium, phosphorus and PTH and adjust the paricalcitol dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Mifepristone with Paricalcitol?
MediHelp rates the interaction as minor. Mifepristone and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone may raise paricalcitol exposure by inhibiting CYP3A4, one of the enzymes that metabolize it. The clinical effect is probably small, but excess vitamin D activity could cause hypercalcemia.
How serious is the interaction between Mifepristone and Paricalcitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphorus and PTH and adjust the paricalcitol dose as needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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