Drug interactions
Mifepristone + Pexidartinib
Severity: Major
Mifepristone and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can increase pexidartinib concentrations by inhibiting CYP3A4. Pexidartinib carries a risk of serious hepatotoxicity that may be amplified at higher exposure.
What this interaction means in plain words
Mifepristone and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Pexidartinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of pexidartinib by mifepristone.
What to do
Avoid the combination if possible. If unavoidable, reduce the pexidartinib dose per labeling and monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Mifepristone with Pexidartinib?
MediHelp rates the interaction as major. Mifepristone and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone can increase pexidartinib concentrations by inhibiting CYP3A4. Pexidartinib carries a risk of serious hepatotoxicity that may be amplified at higher exposure.
How serious is the interaction between Mifepristone and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, reduce the pexidartinib dose per labeling and monitor liver tests closely.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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