Drug interactions
Mifepristone + Quinidine
Severity: Contraindicated
Mifepristone and Quinidine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and can raise levels of quinidine, a narrow therapeutic index drug, and also prolongs QT. The result may be quinidine toxicity and torsades de pointes.
What this interaction means in plain words
Mifepristone and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mifepristone belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition by mifepristone combined with additive QT prolongation.
What to do
Avoid the combination; select an alternative antiarrhythmic or stop quinidine. If mifepristone is needed, monitor ECG and quinidine levels.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Quinidine?
MediHelp rates the interaction as contraindicated. Mifepristone and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone inhibits CYP3A4 and can raise levels of quinidine, a narrow therapeutic index drug, and also prolongs QT. The result may be quinidine toxicity and torsades de pointes.
How serious is the interaction between Mifepristone and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; select an alternative antiarrhythmic or stop quinidine. If mifepristone is needed, monitor ECG and quinidine levels.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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