Drug interactions
Mifepristone + Roflumilast
Severity: Moderate
Mifepristone and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, the enzyme that helps clear roflumilast and its active N-oxide metabolite. Exposure may rise modestly, increasing the chance of gastrointestinal, sleep and psychiatric adverse effects. The effect is generally manageable.
What this interaction means in plain words
Mifepristone and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Roflumilast belongs to Respiratory.
Why it happens
Mifepristone inhibits CYP3A4-mediated metabolism of roflumilast, raising systemic exposure.
What to do
Monitor for roflumilast adverse effects such as diarrhea, weight loss, insomnia and mood changes during the combination. Reduce the roflumilast dose or stop it if these effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Roflumilast
Frequently asked questions
Can I take Mifepristone with Roflumilast?
MediHelp rates the interaction as moderate. Mifepristone and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4, the enzyme that helps clear roflumilast and its active N-oxide metabolite. Exposure may rise modestly, increasing the chance of gastrointestinal, sleep and psychiatric adverse effects. The effect is generally manageable.
How serious is the interaction between Mifepristone and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects such as diarrhea, weight loss, insomnia and mood changes during the combination. Reduce the roflumilast dose or stop it if these effects emerge.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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