Drug interactions
Mifepristone + Selexipag
Severity: Moderate
Mifepristone and Selexipag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may inhibit CYP2C8, which forms the active metabolite of selexipag, and so may alter selexipag exposure. This could increase prostacyclin-type adverse effects such as headache, flushing, diarrhea and hypotension.
What this interaction means in plain words
Mifepristone and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Selexipag belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C8-mediated metabolism of selexipag.
What to do
Consider reducing selexipag to once-daily dosing as advised for moderate CYP2C8 inhibitors, and monitor tolerability and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Mifepristone with Selexipag?
MediHelp rates the interaction as moderate. Mifepristone and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may inhibit CYP2C8, which forms the active metabolite of selexipag, and so may alter selexipag exposure. This could increase prostacyclin-type adverse effects such as headache, flushing, diarrhea and hypotension.
How serious is the interaction between Mifepristone and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing selexipag to once-daily dosing as advised for moderate CYP2C8 inhibitors, and monitor tolerability and blood pressure.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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