Drug interactions
Mifepristone + Sparsentan
Severity: Moderate
Mifepristone and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a CYP3A4 inhibitor and sparsentan is partly metabolized by CYP3A4, so sparsentan exposure may rise. Sparsentan carries risks of hepatotoxicity, hypotension and fluid retention.
What this interaction means in plain words
Mifepristone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Sparsentan belongs to Genitourinary.
Why it happens
Probable CYP3A4 inhibition by mifepristone raising sparsentan levels; the legacy pharmacodynamic rationale is not well established.
What to do
Monitor blood pressure, fluid status and liver enzymes if both are used, and consider an alternative to mifepristone when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Mifepristone with Sparsentan?
MediHelp rates the interaction as moderate. Mifepristone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone is a CYP3A4 inhibitor and sparsentan is partly metabolized by CYP3A4, so sparsentan exposure may rise. Sparsentan carries risks of hepatotoxicity, hypotension and fluid retention.
How serious is the interaction between Mifepristone and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and liver enzymes if both are used, and consider an alternative to mifepristone when possible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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