Drug interactions
Mifepristone + Tinidazole
Severity: Minor
Mifepristone and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a CYP3A4 inhibitor and may raise tinidazole concentrations. With short tinidazole courses the effect is usually small, but nausea and neurological adverse effects could increase.
What this interaction means in plain words
Mifepristone and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Tinidazole belongs to Anti Parasitic.
Why it happens
Mifepristone inhibits CYP3A4, reducing tinidazole metabolism.
What to do
No dose change is routinely needed; monitor for tinidazole adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Tinidazole?
MediHelp rates the interaction as minor. Mifepristone and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone is a CYP3A4 inhibitor and may raise tinidazole concentrations. With short tinidazole courses the effect is usually small, but nausea and neurological adverse effects could increase.
How serious is the interaction between Mifepristone and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for tinidazole adverse effects.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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