Drug interactions
Mifepristone + Treprostinil
Severity: Moderate
Mifepristone and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP2C8 and may increase exposure to treprostinil, which is partly metabolized by CYP2C8. Higher levels may cause hypotension, flushing, headache and diarrhea.
What this interaction means in plain words
Mifepristone and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Treprostinil belongs to Cardiovascular.
Why it happens
Mifepristone inhibits CYP2C8, reducing the metabolism of treprostinil.
What to do
Monitor blood pressure and tolerability, and titrate treprostinil to effect. Reduce the treprostinil dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Treprostinil
Frequently asked questions
Can I take Mifepristone with Treprostinil?
MediHelp rates the interaction as moderate. Mifepristone and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP2C8 and may increase exposure to treprostinil, which is partly metabolized by CYP2C8. Higher levels may cause hypotension, flushing, headache and diarrhea.
How serious is the interaction between Mifepristone and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and titrate treprostinil to effect. Reduce the treprostinil dose if adverse effects emerge.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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