Drug interactions
Mifepristone + Umeclidinium-vilanterol
Severity: Moderate
Mifepristone and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing syndrome, can prolong the QT interval. Adding vilanterol may increase the risk of repolarization abnormalities and arrhythmia, especially if hypokalemia is present.
What this interaction means in plain words
Mifepristone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta-agonist-induced hypokalemia.
What to do
Monitor ECG and serum potassium, correcting hypokalemia promptly. The risk is greatest with chronic high-dose mifepristone therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Mifepristone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone, particularly at the higher doses used for Cushing syndrome, can prolong the QT interval. Adding vilanterol may increase the risk of repolarization abnormalities and arrhythmia, especially if hypokalemia is present.
How serious is the interaction between Mifepristone and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, correcting hypokalemia promptly. The risk is greatest with chronic high-dose mifepristone therapy.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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