Drug interactions
Mifepristone + Verapamil
Severity: Moderate
Mifepristone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit CYP3A4 and are substrates of it, so concentrations of each may rise. This may increase verapamil effects such as bradycardia and hypotension, and mifepristone adverse effects.
What this interaction means in plain words
Mifepristone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Mutual inhibition of CYP3A4 metabolism of verapamil and mifepristone.
What to do
Monitor heart rate, blood pressure and ECG for verapamil toxicity, and reduce the verapamil dose if needed. Watch for increased mifepristone adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Verapamil?
MediHelp rates the interaction as moderate. Mifepristone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs inhibit CYP3A4 and are substrates of it, so concentrations of each may rise. This may increase verapamil effects such as bradycardia and hypotension, and mifepristone adverse effects.
How serious is the interaction between Mifepristone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG for verapamil toxicity, and reduce the verapamil dose if needed. Watch for increased mifepristone adverse effects.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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