Drug interactions
Mifepristone + Vinblastine
Severity: Major
Mifepristone and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is cleared by CYP3A4, and inhibition can raise levels and increase myelosuppression and neurotoxicity. Mifepristone may also affect P-glycoprotein, which could add to this effect.
What this interaction means in plain words
Mifepristone and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Vinblastine belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4 (and possibly P-gp), decreasing vinblastine clearance.
What to do
Avoid the combination where possible; if needed, monitor blood counts and neurological status closely and consider vinblastine dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Mifepristone with Vinblastine?
MediHelp rates the interaction as major. Mifepristone and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vinblastine is cleared by CYP3A4, and inhibition can raise levels and increase myelosuppression and neurotoxicity. Mifepristone may also affect P-glycoprotein, which could add to this effect.
How serious is the interaction between Mifepristone and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, monitor blood counts and neurological status closely and consider vinblastine dose reduction.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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