Drug interactions
Miglitol + Olanzapine
Severity: Moderate
Miglitol and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can raise blood glucose and may reduce the effectiveness of miglitol. Glycemic control may deteriorate after olanzapine is started or increased.
What this interaction means in plain words
Miglitol and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Miglitol belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Olanzapine-induced insulin resistance opposes the glucose-lowering effect of the alpha-glucosidase inhibitor.
What to do
Monitor blood glucose and HbA1c, and adjust antidiabetic therapy as needed. Reassess when olanzapine dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Miglitol with Olanzapine?
MediHelp rates the interaction as moderate. Miglitol and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can raise blood glucose and may reduce the effectiveness of miglitol. Glycemic control may deteriorate after olanzapine is started or increased.
How serious is the interaction between Miglitol and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c, and adjust antidiabetic therapy as needed. Reassess when olanzapine dose changes.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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