Drug interactions
Milnacipran + Naratriptan
Severity: Moderate
Milnacipran and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using milnacipran with naratriptan may increase serotonergic activity and rarely cause serotonin syndrome. The overall risk is low.
What this interaction means in plain words
Milnacipran and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Milnacipran belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from reuptake inhibition and 5-HT1B/1D agonism.
What to do
Counsel on serotonin syndrome symptoms and use the lowest effective triptan dose. Stop both agents and provide supportive care if suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Milnacipran with Naratriptan?
MediHelp rates the interaction as moderate. Milnacipran and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using milnacipran with naratriptan may increase serotonergic activity and rarely cause serotonin syndrome. The overall risk is low.
How serious is the interaction between Milnacipran and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on serotonin syndrome symptoms and use the lowest effective triptan dose. Stop both agents and provide supportive care if suspected.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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