Drug interactions
Milnacipran + Oliceridine
Severity: Moderate
Milnacipran and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid with CNS and respiratory depressant effects, and serotonin syndrome has been reported with opioids combined with serotonergic antidepressants. Milnacipran may add to this risk.
What this interaction means in plain words
Milnacipran and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Milnacipran belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive serotonergic effects, with additive CNS depression as a separate concern.
What to do
Monitor for serotonin syndrome and for sedation or respiratory depression. Use the lowest effective oliceridine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Milnacipran with Oliceridine?
MediHelp rates the interaction as moderate. Milnacipran and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is an opioid with CNS and respiratory depressant effects, and serotonin syndrome has been reported with opioids combined with serotonergic antidepressants. Milnacipran may add to this risk.
How serious is the interaction between Milnacipran and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and for sedation or respiratory depression. Use the lowest effective oliceridine dose.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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