Drug interactions
Milnacipran + Oxaprozin
Severity: Moderate
Milnacipran and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a serotonin-norepinephrine reuptake inhibitor increases the risk of bleeding, particularly gastrointestinal bleeding. The risk is greater in older patients and those with prior ulcers or on other antithrombotic drugs.
What this interaction means in plain words
Milnacipran and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Milnacipran belongs to Central Nervous System; Oxaprozin belongs to Musculoskeletal.
Why it happens
Impaired platelet serotonin uptake by milnacipran reduces platelet aggregation, adding to NSAID platelet inhibition and gastric mucosal injury.
What to do
Monitor for signs of GI bleeding such as black stools or anemia. Consider gastroprotection with a proton pump inhibitor in high-risk patients, or avoid the NSAID.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Milnacipran with Oxaprozin?
MediHelp rates the interaction as moderate. Milnacipran and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with a serotonin-norepinephrine reuptake inhibitor increases the risk of bleeding, particularly gastrointestinal bleeding. The risk is greater in older patients and those with prior ulcers or on other antithrombotic drugs.
How serious is the interaction between Milnacipran and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding such as black stools or anemia. Consider gastroprotection with a proton pump inhibitor in high-risk patients, or avoid the NSAID.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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