Drug interactions
Mipomersen + Pravastatin
Severity: Moderate
Mipomersen and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes, and mipomersen carries a hepatotoxicity warning. Combined use may add to hepatic risk.
What this interaction means in plain words
Mipomersen and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity potential; no established pharmacokinetic interaction.
What to do
Monitor ALT, AST and bilirubin at baseline and regularly during combined therapy; stop mipomersen if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Frequently asked questions
Can I take Mipomersen with Pravastatin?
MediHelp rates the interaction as moderate. Mipomersen and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes, and mipomersen carries a hepatotoxicity warning. Combined use may add to hepatic risk.
How serious is the interaction between Mipomersen and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin at baseline and regularly during combined therapy; stop mipomersen if significant elevations occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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