Drug interactions
Mipomersen + Risperidone
Severity: Moderate
Mipomersen and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause hepatotoxicity with elevated transaminases and hepatic steatosis, and risperidone can occasionally raise liver enzymes. The overlap is a theoretical additive hepatic concern, and mipomersen is no longer widely marketed.
What this interaction means in plain words
Mipomersen and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor ALT, AST and bilirubin according to the mipomersen labeling. Stop or reassess therapy if liver enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mipomersen and Risperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Mipomersen with Risperidone?
MediHelp rates the interaction as moderate. Mipomersen and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause hepatotoxicity with elevated transaminases and hepatic steatosis, and risperidone can occasionally raise liver enzymes. The overlap is a theoretical additive hepatic concern, and mipomersen is no longer widely marketed.
How serious is the interaction between Mipomersen and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin according to the mipomersen labeling. Stop or reassess therapy if liver enzymes rise significantly.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
