Drug interactions
Mipomersen + Trazodone
Severity: Moderate
Mipomersen and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen carries a boxed warning for hepatotoxicity, and trazodone has uncommonly been linked to liver enzyme elevations. Using them together could add to hepatic injury risk, although direct data are lacking.
What this interaction means in plain words
Mipomersen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Check liver enzymes and bilirubin before starting and at regular intervals under the mipomersen monitoring programme. Stop or reassess therapy if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mipomersen and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Mipomersen with Trazodone?
MediHelp rates the interaction as moderate. Mipomersen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen carries a boxed warning for hepatotoxicity, and trazodone has uncommonly been linked to liver enzyme elevations. Using them together could add to hepatic injury risk, although direct data are lacking.
How serious is the interaction between Mipomersen and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before starting and at regular intervals under the mipomersen monitoring programme. Stop or reassess therapy if transaminases rise significantly.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
