Drug interactions
Mirabegron + Nortriptyline
Severity: Moderate
Mirabegron and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline is cleared mainly by CYP2D6, so mirabegron can raise its plasma concentrations. This may cause anticholinergic effects, sedation and cardiac conduction disturbances.
What this interaction means in plain words
Mirabegron and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Nortriptyline belongs to Central Nervous System.
Why it happens
Mirabegron inhibits CYP2D6, reducing nortriptyline metabolism.
What to do
Monitor ECG and anticholinergic effects, and consider checking nortriptyline levels. Reduce the dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Mirabegron with Nortriptyline?
MediHelp rates the interaction as moderate. Mirabegron and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline is cleared mainly by CYP2D6, so mirabegron can raise its plasma concentrations. This may cause anticholinergic effects, sedation and cardiac conduction disturbances.
How serious is the interaction between Mirabegron and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and anticholinergic effects, and consider checking nortriptyline levels. Reduce the dose if toxicity occurs.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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