Drug interactions
Mirabegron + Paroxetine
Severity: Minor
Mirabegron and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is metabolised by CYP2D6 but is also a potent inhibitor of it, so the additional effect of mirabegron is likely small. Conversely, paroxetine can increase mirabegron exposure.
What this interaction means in plain words
Mirabegron and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirabegron belongs to Genitourinary; Paroxetine belongs to Central Nervous System.
Why it happens
Mirabegron inhibits CYP2D6, slightly reducing paroxetine clearance.
What to do
No routine adjustment is needed; monitor for SSRI adverse effects and for increased blood pressure or heart rate from mirabegron.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirabegron with Paroxetine?
MediHelp rates the interaction as minor. Mirabegron and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paroxetine is metabolised by CYP2D6 but is also a potent inhibitor of it, so the additional effect of mirabegron is likely small. Conversely, paroxetine can increase mirabegron exposure.
How serious is the interaction between Mirabegron and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for SSRI adverse effects and for increased blood pressure or heart rate from mirabegron.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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