Drug interactions
Mirabegron + Timolol
Severity: Moderate
Mirabegron and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol is partly metabolised by CYP2D6, and mirabegron can increase its plasma levels. This may enhance beta-blocker effects such as bradycardia and hypotension, mainly with oral timolol.
What this interaction means in plain words
Mirabegron and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Timolol belongs to Cardiovascular.
Why it happens
Mirabegron inhibits CYP2D6, reducing timolol metabolism.
What to do
Monitor heart rate and blood pressure when starting or stopping mirabegron, and reduce the timolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Mirabegron with Timolol?
MediHelp rates the interaction as moderate. Mirabegron and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol is partly metabolised by CYP2D6, and mirabegron can increase its plasma levels. This may enhance beta-blocker effects such as bradycardia and hypotension, mainly with oral timolol.
How serious is the interaction between Mirabegron and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping mirabegron, and reduce the timolol dose if bradycardia or hypotension develops.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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