Drug interactions
Mirabegron + Tolterodine
Severity: Minor
Mirabegron and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate CYP2D6 inhibitor and can raise exposure to CYP2D6 substrates such as tolterodine. The combination is used deliberately in overactive bladder, and the pharmacokinetic increase is modest. Combined therapy may increase heart rate or blood pressure and anticholinergic effects.
What this interaction means in plain words
Mirabegron and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirabegron belongs to Genitourinary; Tolterodine belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing tolterodine clearance.
What to do
No empirical dose change is needed, but monitor heart rate, blood pressure and anticholinergic effects. Adjust the tolterodine dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Mirabegron with Tolterodine?
MediHelp rates the interaction as minor. Mirabegron and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirabegron is a moderate CYP2D6 inhibitor and can raise exposure to CYP2D6 substrates such as tolterodine. The combination is used deliberately in overactive bladder, and the pharmacokinetic increase is modest. Combined therapy may increase heart rate or blood pressure and anticholinergic effects.
How serious is the interaction between Mirabegron and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed, but monitor heart rate, blood pressure and anticholinergic effects. Adjust the tolterodine dose if adverse effects emerge.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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