Drug interactions
Mirtazapine + Orphenadrine
Severity: Moderate
Mirtazapine and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a centrally acting anticholinergic muscle relaxant that causes drowsiness and dizziness. Together with mirtazapine, excess sedation and impaired alertness may occur, and anticholinergic effects may also add up in susceptible patients.
What this interaction means in plain words
Mirtazapine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and antihistaminic/anticholinergic effects.
What to do
Monitor for excessive sedation, confusion and anticholinergic effects, particularly in older adults. Reduce doses if drowsiness is troublesome and warn against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Orphenadrine?
MediHelp rates the interaction as moderate. Mirtazapine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a centrally acting anticholinergic muscle relaxant that causes drowsiness and dizziness. Together with mirtazapine, excess sedation and impaired alertness may occur, and anticholinergic effects may also add up in susceptible patients.
How serious is the interaction between Mirtazapine and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, confusion and anticholinergic effects, particularly in older adults. Reduce doses if drowsiness is troublesome and warn against driving.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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