Drug interactions
Mirtazapine + Selegiline transdermal
Severity: Contraindicated
Mirtazapine and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor, and its combination with mirtazapine may precipitate serotonin syndrome or hypertensive effects. Labeling for transdermal selegiline advises against combination with antidepressants.
What this interaction means in plain words
Mirtazapine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition combined with mirtazapine's serotonergic and noradrenergic activity.
What to do
Avoid the combination and observe a washout period when switching, as specified in the product labeling for each agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Mirtazapine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO inhibitor, and its combination with mirtazapine may precipitate serotonin syndrome or hypertensive effects. Labeling for transdermal selegiline advises against combination with antidepressants.
How serious is the interaction between Mirtazapine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and observe a washout period when switching, as specified in the product labeling for each agent.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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