Drug interactions
Mirtazapine + Quazepam
Severity: Moderate
Mirtazapine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic. With mirtazapine, sedation, dizziness, psychomotor impairment and next-day drowsiness may be increased, with a greater fall risk in older adults.
What this interaction means in plain words
Mirtazapine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 antagonism.
What to do
Use the lowest effective doses and monitor for daytime sedation and falls. Avoid alcohol and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Quazepam?
MediHelp rates the interaction as moderate. Mirtazapine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic. With mirtazapine, sedation, dizziness, psychomotor impairment and next-day drowsiness may be increased, with a greater fall risk in older adults.
How serious is the interaction between Mirtazapine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for daytime sedation and falls. Avoid alcohol and counsel on driving.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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