Drug interactions
Mirtazapine + Sufentanil sl
Severity: Moderate
Mirtazapine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine enhances serotonergic transmission and opioids such as sufentanil have weak serotonergic activity, so serotonin syndrome is possible though uncommon. Additive sedation and respiratory depression are also a concern.
What this interaction means in plain words
Mirtazapine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity plus additive CNS depression.
What to do
Monitor for agitation, tremor, hyperreflexia, hyperthermia and excess sedation, especially at initiation and after dose increases. Stop one agent if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Sufentanil sl?
MediHelp rates the interaction as moderate. Mirtazapine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine enhances serotonergic transmission and opioids such as sufentanil have weak serotonergic activity, so serotonin syndrome is possible though uncommon. Additive sedation and respiratory depression are also a concern.
How serious is the interaction between Mirtazapine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, hyperthermia and excess sedation, especially at initiation and after dose increases. Stop one agent if serotonin toxicity is suspected.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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