Drug interactions
Mirtazapine + Sumatriptan intranasal
Severity: Moderate
Mirtazapine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on serotonin pathways, and combined use has been linked in theory and rare reports to serotonin syndrome. The risk is generally low with mirtazapine.
What this interaction means in plain words
Mirtazapine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects (5-HT1B/1D agonism plus enhanced noradrenergic and serotonergic release).
What to do
Counsel patients to report agitation, tremor, sweating, diarrhea or fever after triptan use. Avoid frequent repeated dosing of the triptan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Mirtazapine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on serotonin pathways, and combined use has been linked in theory and rare reports to serotonin syndrome. The risk is generally low with mirtazapine.
How serious is the interaction between Mirtazapine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, sweating, diarrhea or fever after triptan use. Avoid frequent repeated dosing of the triptan.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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