Drug interactions
Mirtazapine + Thiothixene
Severity: Moderate
Mirtazapine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, so together they can cause excessive drowsiness and impaired alertness. Additive effects on QT interval and on orthostatic blood pressure are also possible.
What this interaction means in plain words
Mirtazapine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through histamine H1 and other receptor antagonism.
What to do
Start with low doses and monitor sedation and orthostatic blood pressure. Consider an ECG if other QT-prolonging risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Thiothixene?
MediHelp rates the interaction as moderate. Mirtazapine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, so together they can cause excessive drowsiness and impaired alertness. Additive effects on QT interval and on orthostatic blood pressure are also possible.
How serious is the interaction between Mirtazapine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation and orthostatic blood pressure. Consider an ECG if other QT-prolonging risk factors exist.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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