Drug interactions
Mirtazapine + Triazolam
Severity: Moderate
Mirtazapine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can increase drowsiness, memory impairment, and falls. The effects may be greater in older or frail patients.
What this interaction means in plain words
Mirtazapine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression (GABA-A enhancement plus histamine H1 blockade).
What to do
Use the lowest effective doses for the shortest time, and counsel on avoiding driving and alcohol. Monitor older patients closely for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Triazolam?
MediHelp rates the interaction as moderate. Mirtazapine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can increase drowsiness, memory impairment, and falls. The effects may be greater in older or frail patients.
How serious is the interaction between Mirtazapine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time, and counsel on avoiding driving and alcohol. Monitor older patients closely for sedation.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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