Drug interactions
Mirtazapine + Trifluoperazine
Severity: Moderate
Mirtazapine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, so together they can produce marked drowsiness and impaired psychomotor performance. Both also carry some QT-prolonging potential, adding to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Mirtazapine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via H1 and other receptor blockade, plus additive QT prolongation.
What to do
Monitor sedation and consider an ECG if there are other QT risk factors. Keep electrolytes within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Trifluoperazine?
MediHelp rates the interaction as moderate. Mirtazapine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, so together they can produce marked drowsiness and impaired psychomotor performance. Both also carry some QT-prolonging potential, adding to arrhythmia risk in susceptible patients.
How serious is the interaction between Mirtazapine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and consider an ECG if there are other QT risk factors. Keep electrolytes within normal range.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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