Drug interactions
Mirtazapine + Triprolidine
Severity: Moderate
Mirtazapine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine has strong H1-antihistamine activity and is markedly sedating, so adding triprolidine increases drowsiness and impairs psychomotor performance. The effect may be pronounced at the start of therapy and in older adults.
What this interaction means in plain words
Mirtazapine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive H1-receptor blockade and CNS depression.
What to do
Monitor for excessive sedation and advise against driving or operating machinery. Prefer a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Triprolidine?
MediHelp rates the interaction as moderate. Mirtazapine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine has strong H1-antihistamine activity and is markedly sedating, so adding triprolidine increases drowsiness and impairs psychomotor performance. The effect may be pronounced at the start of therapy and in older adults.
How serious is the interaction between Mirtazapine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise against driving or operating machinery. Prefer a non-sedating antihistamine.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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