Drug interactions
Mirtazapine + Yohimbine
Severity: Minor
Mirtazapine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist, as is mirtazapine, so they share a mechanism and may add to noradrenergic effects such as anxiety, tachycardia and blood pressure elevation. The net effect on sedation is unpredictable.
What this interaction means in plain words
Mirtazapine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Overlapping alpha-2 adrenergic antagonism with unclear net clinical effect.
What to do
Monitor blood pressure, heart rate and anxiety symptoms if both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Yohimbine?
MediHelp rates the interaction as minor. Mirtazapine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist, as is mirtazapine, so they share a mechanism and may add to noradrenergic effects such as anxiety, tachycardia and blood pressure elevation. The net effect on sedation is unpredictable.
How serious is the interaction between Mirtazapine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and anxiety symptoms if both are used.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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