Drug interactions
Mitotane + Paclitaxel
Severity: Moderate
Mitotane and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a potent CYP3A4 inducer and may lower paclitaxel concentrations, potentially reducing efficacy. The induction can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Mitotane and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Mitotane induces CYP3A4 (and possibly other enzymes), increasing paclitaxel clearance.
What to do
Monitor for reduced treatment response and consider alternative therapy; allow for prolonged enzyme induction after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Paclitaxel?
MediHelp rates the interaction as moderate. Mitotane and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a potent CYP3A4 inducer and may lower paclitaxel concentrations, potentially reducing efficacy. The induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Mitotane and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced treatment response and consider alternative therapy; allow for prolonged enzyme induction after mitotane discontinuation.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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