Drug interactions
Mitotane + Roflumilast
Severity: Moderate
Mitotane and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer with a long-lasting effect and can substantially lower roflumilast and active metabolite exposure. This may reduce the clinical benefit of roflumilast in COPD.
What this interaction means in plain words
Mitotane and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Roflumilast belongs to Respiratory.
Why it happens
Mitotane induces CYP3A4, increasing roflumilast metabolism.
What to do
Monitor COPD control and exacerbation frequency. Consider an alternative therapy if roflumilast is ineffective, and note the effect persists after mitotane is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Roflumilast?
MediHelp rates the interaction as moderate. Mitotane and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer with a long-lasting effect and can substantially lower roflumilast and active metabolite exposure. This may reduce the clinical benefit of roflumilast in COPD.
How serious is the interaction between Mitotane and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor COPD control and exacerbation frequency. Consider an alternative therapy if roflumilast is ineffective, and note the effect persists after mitotane is stopped.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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