Drug interactions
Mitotane + Tamsulosin
Severity: Moderate
Mitotane and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer that can substantially reduce tamsulosin concentrations. This may lead to loss of efficacy for urinary symptoms, and the induction persists for weeks after mitotane is stopped.
What this interaction means in plain words
Mitotane and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Tamsulosin belongs to Genitourinary.
Why it happens
Mitotane induces CYP3A4, increasing tamsulosin clearance.
What to do
Monitor urinary symptom response and titrate tamsulosin as needed. Reassess the dose after mitotane is discontinued because induction wanes slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Tamsulosin?
MediHelp rates the interaction as moderate. Mitotane and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer that can substantially reduce tamsulosin concentrations. This may lead to loss of efficacy for urinary symptoms, and the induction persists for weeks after mitotane is stopped.
How serious is the interaction between Mitotane and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom response and titrate tamsulosin as needed. Reassess the dose after mitotane is discontinued because induction wanes slowly.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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