Drug interactions
Mitotane + Vinblastine
Severity: Moderate
Mitotane and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can lower vinblastine concentrations, possibly reducing antitumour efficacy. The induction effect may persist for weeks after mitotane is stopped because of its long half-life.
What this interaction means in plain words
Mitotane and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing hepatic and intestinal metabolism of vinblastine.
What to do
Monitor for reduced response to vinblastine and consider an alternative regimen if mitotane is required. Be aware that induction can persist after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Vinblastine?
MediHelp rates the interaction as moderate. Mitotane and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can lower vinblastine concentrations, possibly reducing antitumour efficacy. The induction effect may persist for weeks after mitotane is stopped because of its long half-life.
How serious is the interaction between Mitotane and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to vinblastine and consider an alternative regimen if mitotane is required. Be aware that induction can persist after mitotane discontinuation.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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