Drug interactions
Mobocertinib + Risperidone
Severity: Major
Mobocertinib and Risperidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib causes dose-related QT prolongation and risperidone adds to the risk. The combination may increase the chance of torsades de pointes.
What this interaction means in plain words
Mobocertinib and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation.
What to do
Avoid if possible. If unavoidable, monitor ECG and electrolytes frequently and reduce or hold mobocertinib per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Okedi 100mg powder and solvent for prolonged-release suspension for injection pre-filled syringes - SmPC sections 4.3/4.5 (class statement: medicinal products known to prolong the QT interval; "Caution is advised when prescribing OKEDI with medicinal products known to prolong the QT interval") — electronic medicines compendium (UK SmPC)
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Mobocertinib with Risperidone?
MediHelp rates the interaction as major. Mobocertinib and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib causes dose-related QT prolongation and risperidone adds to the risk. The combination may increase the chance of torsades de pointes.
How serious is the interaction between Mobocertinib and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, monitor ECG and electrolytes frequently and reduce or hold mobocertinib per labeling.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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