Drug interactions
Modafinil + Motherwort
Severity: Minor
Modafinil and Motherwort: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort has traditional sedative properties that may oppose the effect of modafinil. Evidence on the interaction is limited and its clinical effect is uncertain.
What this interaction means in plain words
Modafinil and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible opposing CNS effects; mechanism not well established.
What to do
Monitor for reduced modafinil benefit or additive sedation and consider discontinuing the herbal product if wakefulness is impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Motherwort?
MediHelp rates the interaction as minor. Modafinil and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort has traditional sedative properties that may oppose the effect of modafinil. Evidence on the interaction is limited and its clinical effect is uncertain.
How serious is the interaction between Modafinil and Motherwort?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced modafinil benefit or additive sedation and consider discontinuing the herbal product if wakefulness is impaired.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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