Drug interactions
Modafinil + Nefazodone
Severity: Moderate
Modafinil and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may increase modafinil concentrations, increasing adverse effects such as anxiety, insomnia and headache. Modafinil's weak CYP3A4 induction may also lower nefazodone levels.
What this interaction means in plain words
Modafinil and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by nefazodone reduces modafinil clearance.
What to do
Monitor for modafinil adverse effects and consider a lower modafinil dose; monitor antidepressant response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Nefazodone?
MediHelp rates the interaction as moderate. Modafinil and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may increase modafinil concentrations, increasing adverse effects such as anxiety, insomnia and headache. Modafinil's weak CYP3A4 induction may also lower nefazodone levels.
How serious is the interaction between Modafinil and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects and consider a lower modafinil dose; monitor antidepressant response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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