Drug interactions
Modafinil + Olanzapine
Severity: Minor
Modafinil and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is sedating and modafinil is wake-promoting, so their effects on alertness oppose each other. No consistent harmful interaction is established, but modafinil may reduce the sedation from olanzapine and in some patients could aggravate agitation or psychiatric symptoms.
What this interaction means in plain words
Modafinil and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
No dose adjustment is generally required. Monitor psychiatric status, particularly agitation, anxiety or psychosis, and sedation level.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Olanzapine
Frequently asked questions
Can I take Modafinil with Olanzapine?
MediHelp rates the interaction as minor. Modafinil and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine is sedating and modafinil is wake-promoting, so their effects on alertness oppose each other. No consistent harmful interaction is established, but modafinil may reduce the sedation from olanzapine and in some patients could aggravate agitation or psychiatric symptoms.
How serious is the interaction between Modafinil and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required. Monitor psychiatric status, particularly agitation, anxiety or psychosis, and sedation level.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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