Drug interactions
Modafinil + Opium tincture
Severity: Minor
Modafinil and Opium tincture: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture causes sedation and respiratory depression, while modafinil is wakefulness-promoting and may partly mask drowsiness. The alertness may give a false impression of safety while opioid respiratory effects persist.
What this interaction means in plain words
Modafinil and Opium tincture have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS pharmacodynamic effects; no established pharmacokinetic interaction.
What to do
Dose the opioid according to pain and respiratory status rather than alertness, and monitor respiratory rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Opium tincture?
MediHelp rates the interaction as minor. Modafinil and Opium tincture have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opium tincture causes sedation and respiratory depression, while modafinil is wakefulness-promoting and may partly mask drowsiness. The alertness may give a false impression of safety while opioid respiratory effects persist.
How serious is the interaction between Modafinil and Opium tincture?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose the opioid according to pain and respiratory status rather than alertness, and monitor respiratory rate.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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