Drug interactions
Modafinil + Phendimetrazine
Severity: Moderate
Modafinil and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CNS stimulants, so combined use may increase insomnia, anxiety, tachycardia and blood pressure. The risk is higher in patients with cardiovascular disease.
What this interaction means in plain words
Modafinil and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and sympathomimetic stimulation.
What to do
Monitor blood pressure, heart rate and sleep; avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Phendimetrazine?
MediHelp rates the interaction as moderate. Modafinil and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CNS stimulants, so combined use may increase insomnia, anxiety, tachycardia and blood pressure. The risk is higher in patients with cardiovascular disease.
How serious is the interaction between Modafinil and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sleep; avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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