Drug interactions
Modafinil + Phenylephrine po
Severity: Minor
Modafinil and Phenylephrine po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral phenylephrine is a sympathomimetic decongestant that can raise blood pressure, and modafinil also has stimulant and mild pressor effects. Together they may cause palpitations, insomnia or hypertension.
What this interaction means in plain words
Modafinil and Phenylephrine po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sympathomimetic and CNS stimulant effects.
What to do
Limit decongestant use and monitor blood pressure in hypertensive patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Phenylephrine po?
MediHelp rates the interaction as minor. Modafinil and Phenylephrine po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral phenylephrine is a sympathomimetic decongestant that can raise blood pressure, and modafinil also has stimulant and mild pressor effects. Together they may cause palpitations, insomnia or hypertension.
How serious is the interaction between Modafinil and Phenylephrine po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit decongestant use and monitor blood pressure in hypertensive patients.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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