Drug interactions
Modafinil + Phenylephrine
Severity: Moderate
Modafinil and Phenylephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can raise blood pressure and heart rate, so combined use may produce additive cardiovascular stimulation. This matters most in patients with hypertension or cardiac disease.
What this interaction means in plain words
Modafinil and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Why it happens
Additive pharmacodynamic sympathomimetic and central stimulant effects on blood pressure and heart rate.
What to do
Monitor blood pressure and heart rate when systemic phenylephrine is used with modafinil. Avoid decongestant use in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Phenylephrine?
MediHelp rates the interaction as moderate. Modafinil and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can raise blood pressure and heart rate, so combined use may produce additive cardiovascular stimulation. This matters most in patients with hypertension or cardiac disease.
How serious is the interaction between Modafinil and Phenylephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when systemic phenylephrine is used with modafinil. Avoid decongestant use in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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