Drug interactions
Modafinil + Pimozide
Severity: Moderate
Modafinil and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide prolongs the QT interval and is metabolised mainly by CYP3A4 and CYP2D6. Modafinil may induce CYP3A4, potentially lowering pimozide levels, and its stimulant effects oppose pimozide sedation; the net effect is unpredictable.
What this interaction means in plain words
Modafinil and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Possible CYP3A4 induction by modafinil altering pimozide exposure, plus opposing CNS effects.
What to do
Monitor clinical response and obtain an ECG if either drug is adjusted. Adjust the pimozide dose according to symptom control and QT findings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Modafinil with Pimozide?
MediHelp rates the interaction as moderate. Modafinil and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide prolongs the QT interval and is metabolised mainly by CYP3A4 and CYP2D6. Modafinil may induce CYP3A4, potentially lowering pimozide levels, and its stimulant effects oppose pimozide sedation; the net effect is unpredictable.
How serious is the interaction between Modafinil and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and obtain an ECG if either drug is adjusted. Adjust the pimozide dose according to symptom control and QT findings.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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