Drug interactions
Modafinil + Quazepam
Severity: Minor
Modafinil and Quazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a hypnotic benzodiazepine and modafinil promotes wakefulness, so they oppose each other. Modafinil's weak CYP3A4 induction might slightly lower quazepam levels.
What this interaction means in plain words
Modafinil and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects and possible mild CYP3A4 induction.
What to do
Monitor hypnotic efficacy and avoid using modafinil to override benzodiazepine sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Quazepam?
MediHelp rates the interaction as minor. Modafinil and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quazepam is a hypnotic benzodiazepine and modafinil promotes wakefulness, so they oppose each other. Modafinil's weak CYP3A4 induction might slightly lower quazepam levels.
How serious is the interaction between Modafinil and Quazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hypnotic efficacy and avoid using modafinil to override benzodiazepine sedation.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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