Drug interactions
Modafinil + Selegiline transdermal
Severity: Major
Modafinil and Selegiline transdermal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline provides systemic MAO inhibition at antidepressant doses. Combined with modafinil, which has stimulant and mild sympathomimetic properties, there is a risk of elevated blood pressure and, rarely, hypertensive reactions.
What this interaction means in plain words
Modafinil and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition combined with modafinil's dopaminergic and noradrenergic effects may produce additive pressor responses.
What to do
Avoid unless benefit clearly outweighs risk; if combined, monitor blood pressure closely, especially after dose changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Selegiline transdermal?
MediHelp rates the interaction as major. Modafinil and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Transdermal selegiline provides systemic MAO inhibition at antidepressant doses. Combined with modafinil, which has stimulant and mild sympathomimetic properties, there is a risk of elevated blood pressure and, rarely, hypertensive reactions.
How serious is the interaction between Modafinil and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless benefit clearly outweighs risk; if combined, monitor blood pressure closely, especially after dose changes.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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