Drug interactions
Modafinil + Sofosbuvir / velpatasvir
Severity: Minor
Modafinil and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir is a weak inhibitor of some CYP enzymes and transporters, but any rise in modafinil exposure is likely small. Clinical significance is unlikely.
What this interaction means in plain words
Modafinil and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by velpatasvir.
What to do
No adjustment needed; monitor for modafinil adverse effects such as headache or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Modafinil and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir is a weak inhibitor of some CYP enzymes and transporters, but any rise in modafinil exposure is likely small. Clinical significance is unlikely.
How serious is the interaction between Modafinil and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor for modafinil adverse effects such as headache or insomnia.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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