Drug interactions
Modafinil + Thiothixene
Severity: Moderate
Modafinil and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is a sedating antipsychotic and modafinil is a wake-promoting agent, so their effects on alertness oppose each other. Modafinil may reduce daytime sedation but could also aggravate agitation, anxiety or psychotic symptoms in susceptible patients. Thiothixene also lowers seizure threshold and modafinil may add to neuropsychiatric effects.
What this interaction means in plain words
Modafinil and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic CNS effects, with possible additive neuropsychiatric effects; no well-established pharmacokinetic mechanism.
What to do
Monitor for worsening psychosis, agitation, insomnia and anxiety when modafinil is added to thiothixene. Reassess the need for modafinil if psychiatric symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Thiothixene?
MediHelp rates the interaction as moderate. Modafinil and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is a sedating antipsychotic and modafinil is a wake-promoting agent, so their effects on alertness oppose each other. Modafinil may reduce daytime sedation but could also aggravate agitation, anxiety or psychotic symptoms in susceptible patients. Thiothixene also lowers seizure threshold and modafinil may add to neuropsychiatric effects.
How serious is the interaction between Modafinil and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening psychosis, agitation, insomnia and anxiety when modafinil is added to thiothixene. Reassess the need for modafinil if psychiatric symptoms emerge.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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